Question
Can ibuprofen (chronic use or otherwise) cause water weight gain?

Answer
Hi Angela and thanks for writing,

Yes, "Fluid retention (edema), blood clots, heart attacks, hypertension and heart failure have also been associated with the use of NSAIDs".

excerpts from:
http://www.medicinenet.com/ibuprofen/article.htm

Hope this helps answer your question,

All my best,
Margot