Question
If there any research that chiropractic care can help with Common Variable Immunodeficiency. I produce low IgG and IgM both being less then half of normal levels. I am currently receiving IVIG therapy once a month. The Common Variable Immunodeficiency effect my asthma, with frequent sinus infection, ear pain with fluid backup also. I also have the muscle pain that is part of the disease.
When I had spinal x-ray done when I first start with chiropractic care, I was told my bottom of the skull and C1 has no space between them or very little space, does this have any relationship with the  Common Variable Immunodeficiency.


Answer
I am not familiar with any research specifically showing that chiropractic care may positively influence people with Common Variable Immunodeficiency (CVID), nor did a literature search of indexed publications in the Manual Alternative and Natural Therapy Index System reveal any data regarding chiropractic and this disorder. I am also not aware of any scientific correlations made between the orientation of the atlas (C1 vertebra) the occiput (skull), and CVID.

CVID is the most prevalent primary immunodeficiency disorder in which numerous immune-system abnormalities are reported, the most common of which is defective antibody formation [1]. CVID is suspected to be caused by genetic factors [1] rather than by structural problems.

Chiropractors, however, have historically and anecdotally reported (mostly in the form of case reports) some patients who have shown improvement (to varying degrees) with non-musculoskeletal problems such as asthma, sinusitis, and ear pain, and chiropractors have generally focused on manipulations/adjustments of the upper cervical spine with regard to attempting to positively influence the immune system.

One literature review found that a minority of patients with self-reported non-musculoskeletal symptoms such as allergy, asthma, breathing, circulation, digestion, hearing, heart function, ringing in the ears, sinus problems, urination, and others reported definite improvement after chiropractic care, and very few report definite worsening [2].

I have encountered patients in my practice that presented with musculoskeletal problems, and after manipulation/adjustment of the spine, reported improvements in ear pain, the severity of their asthma, or other non-musculoskeletal problems. However, the consensus of researchers with regard to the non-musculoskeletal benefits of chiropractic care is that further research is needed in this area.

I hope that this answer was of help to you.

References:

1. Schwartz RA, Modak RM. Common Variable Immunodeficiency. Accessed on 03/21/07 at: http://www.emedicine.com/derm/topic870.htm

2. Leboeuf-Yde C, Pedersen EN, Bryner P, et al. Self-reported nonmusculoskeletal responses to chiropractic intervention: a multination survey. 2005: J Manipulative Physiol Ther. Jun Vol. 28(5):  294-302; discussion 365-6.