Background Raynaud phenomenon manifests as recurrent vasospasm of the fingers and toes and us

Background Polymyositis is an idiopathic inflammatory myopathy that causes symmetrical, proxi

Background Paget disease is a localized disorder of bone remodeling that typically begins wit

Practice Essentials Osteoporosis (see the image below) is the most common metabolic bone dise

Background Osteopetrosis is a clinical syndrome characterized by the failure of osteoclasts t

Background Osteomyelitis is inflammation of the bone caused by an infecting organism. Althoug

Practice Essentials Osteoarthritis (see the image below) is the most common type of joint dis

Background Friedreich ataxia (FA) is the prototype of all forms of progressive ataxia, and it

Background Nonarticular rheumatic pain syndromes can be classified into five general categori

Background Mixed connective-tissue disease (MCTD) was first recognized by Sharp and colleague

Practice Essentials Lupus nephritis is histologically evident in most patients with systemic

Practice EssentialsLimb-girdle muscular dystrophy refers to a group of disorders that cause weakness and wasting of the

Practice Essentials Primary syndromes of generalized autonomic failure include the following:

Background Hypertrophic osteoarthropathy (HOA) is a syndrome of clubbing of the digits, perio

Practice Essentials Gout and pseudogout are the 2 most common crystal-induced arthropathies.

Background Focal atrophy of an individual muscle or group of muscles, often encountered clini

Background Felty syndrome (FS), which was first described in 1924, is a potentially serious c

Background Eosinophilic fasciitis (EF), also called Shulman syndrome, is a rare, localized fi

Background In October 1989, the health department in New Mexico was notified of 3 patients wi

Background Beta-2 ̶ microglobulin (beta-2m) amyloidosis is a disabling condition that affects