The bone structure within the human body goes through a process whereby new bone is laid down to replace the old. This cycle maintains normal levels of calcium in the blood circulation. Individuals afflicted with Paget’s disease suffer a kink in the works whereby this cycle does not go as planned. New bone formation is irregular, resulting in enlarged sizes whilst loosing out on tensile strength expected of standard bone. Being less dense, the affected bone is brittle and more prone to breakage as compared to its regular counterpart.

This disease generally affects the adult population. However, rare forms are documented in children. Its causes may be due to genetic disorders whereby certain virus infections trigger its onset. Discovery is normally accidental due to tests conducted for other reasons. Unless there is significant bone deformity or pain, it is generally undetected as symptoms do not show themselves in obvious manner. Medication may help to prevent further bone breakdown as well as for pain management. Surgery to rectify deformities may be an option for some.

Of the same name, Paget’s disease also refers to an affliction of the skin on the nipple. Its presence generally infers some underlying cancer of the breast as it is thought to be caused by cancer cells breaking off from an internal tumor, moving to the skin surface and manifesting itself. Others conjecture no presence of existing tumors as diseased cells cause this ailment on their own. Although most sufferers are of the female adult population, extremely rare cases are seen in the male gender.

Whichever the case, any abnormality forming on the nipple skin must be taken seriously to ensure early detection of other possible problems within the breast area. Although surgery is the recommended mode of treatment, seeking immediate medical attention hopefully reduces the need for drastic procedures. Follow-up treatment normally comes in the form of radiotherapy and chemotherapy to destroy whatever remaining diseased cells. Hormonal therapy manages hormone production and prevents the stimulation of cancer cell growth.

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