In the recent 20 years, hyaluronic acid as biological material was developed rapidly in its applications, the industrial applications field was expanding. Hyaluronic acid played an important role on alleviating the pain of people suffering disease and improved people's quality of life.

Hyaluronic acid is a polymer mucooplysaccharide which by the DN-acetyl-glucosamine and D-glucuronic acid mucopolysaccharide as structural units, hyaluronic acid molecules can be repeatly linked by 25,000 pairs of sugars. The molecular weight of the hyaluronic acid polymer size ranges from 5000 to 20,000,000 Daltons in the body. Hyaluronate is generally referred to its sodium salt, namely sodium hyaluronate, HA for short, customarily still called hyaluronic acid. In China, sodium hyaluronate as a medical device knew as the "medical sodium hyaluronate gel"; as medicines, the current listed products have sodium hyaluronate injections and sodium hyaluronate eye drops. Sodium hyaluronate eye drops used for dry eye, corneal epithelial mechanical injury; Sodium hyaluronate injection as a joint function improving agent used for the bone articular injection of bone joint disease.

Sodium hyaluronate raw materials can be divided into pharmaceutical grade, topical grade, food grade. The major source of Chinese Sodium Hyaluronate raw material is comb extraction and fermentation. In the treatment areas, in the mid-1990s, hyaluronic acid preparation products began to enter clinical applications, the products no matter used in ophthalmology, orthopedics or surgery have achieved good clinical efficacy. In recent 10 years, the demand for sodium hyaluronate products in the pharmaceutical raw materials field continuous development. With people living, life quality requires continuous improvement, the urban population accelerated aging (senile diseases such as cataracts, osteoarthritis), market demand continues to expand.

Medical sodium hyaluronate gel has the following main applications: in ophthalmology, as viscoelastic substances used in ophthalmic surgery; In department of orthopaedics, as joint function improving agents for articular cavity injection of osteoarthrosis patients; in surgery or obstetrics and Gynecology, as blocking agent used in post-operative preventing adhesion of organs tissue; in the plastic surgery non-surgical cosmetic as a dermal filler for wrinkles, lips, nose, etc..

Sodium hyaluronate used as fillers in the field of non-surgical cosmetic injectable is the most anticipated. In orthopedic surgery, after filler filling in dermis, it needs to keep a very long duration. The crosslinked hyaluronic acid as effective skin filler, since the crosslinked hyaluronic acid has a larger, more stable molecule, both have the same biocompatibility, viscoelasticity, maintain a longer time in the organization. In current international market, all the hyaluronic acid raw materials used in dermal filler products are derived from biological fermentation, the cross-linking agent used in the hyaluronic acid crosslinking reaction are mostly 1,4 - butanediol diglycidyl ether (BDDE).

Currently, hyaluronic acid has shown its good development prospects and importance in the medical, medical beauty and cosmetics industry applications. In recent years, hyaluronic acid as non-surgical cosmetic injectable product is particularly prominent. In clinical application of injecting hyaluronic acid products, should be focusing on the product's safety and effectiveness. Insiders expect sodium hyaluronate products in the ophthalmology, orthopedics, surgical fields application can be further steady development; look forward to have more injectable hyaluronic acid products which has technical content to enter the market as soon as possible; also look forward to under the industry continues to regulate, supervision, non-surgical injectable hyaluronic acid products market can get healthy and rapid development.

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